A new Cluster publication in Advanced Functional Materials highlights the transformative potential of printed electronics for interfacing with biological systems, from single cells to organoids. The review article by first author Young Scientist Mahsa K. Saghafi summarizes the recent advancements in this rapidly growing field and showcases its diverse applications in biosensing, neural interfacing, and organ-on-a-chip technologies. The article resulted from the collaboration of researchers from KIT and Heidelberg University, including PIs Motomu Tanaka, Martin Bastmeyer, Christine Selhuber-Unkel, Ute Schepers, and Jasmin Aghassi-Hagmann.