A groundbreaking paper in organoid research, published in Nature Nanotechnology by Cluster Doctoral Researchers Cassian Afting, Tobias Walther, and Christina Schlagheck, along with Principal Investigators Ulrich Schwarz, Joachim Wittbrodt, and Kerstin Göpfrich, involves nanoengineered DNA microbeads that enable precise control of signaling in organoids. These microbeads enhance organoid development by providing essential biochemical cues. This technology is particularly useful for modeling complex tissues such as the retinal pigmented epithelium and holds promise for advancements in organ models, personalized medicine and disease modeling.