A new episode of our Explain Like I’m Five series is now live, exploring the fascinating world of human brain organoids. Lízia Branco, a Cluster Doctoral Researcher at the Karlsruhe Institute of Technology (KIT), demonstrates how lab-grown organoids made from stem cells can be used to study brain development and neurological disorders, eliminating the need for animal testing. Lízia combines her background in physics with neuroscience to apply imaging, data analysis, and machine learning to reveal how genetic and environmental factors influence the brain. The episode also discusses whether AI could play a role in detecting and helping to “fix” brain disorders.