Controlling Differentiation and Function of Organoids (C2.2)

Project C2.2 aims to expand the understanding of how the 3D microenvironment, particularly biochemical cues and contractile intracellular forces, influences differentiation into brain, intestinal, and other organoids.

Locally tunable 3D architectures are key to achieving precise and dynamic control of organoid development, utilizing stimulus-responsive materials. These architectures will be employed alongside 3D-printed microfluidics at micrometer precision. Our strategy will advance material-controlled structural and functional organoid development, opening possibilities such as using organoids to study metastasis and other complex biological processes.